BLOODCARE products are an excellent local haemostatic agents, with the haemostatic effect based on the oxidised cellulose features. They are indicated as a haemostatic device used to arrest capillary and minor venous bleeding and parenchymateous or osseous bleeding from resected or injured organ surfaces during surgical interventions.
Having taken the product out of the sterile packages, BLOODCARE can be immediately applied on to the bleeding area.
BLOODCARE is an efficient local haemostat, the haemostatic effect is almost immediate. The full haemostasis is achieved by 2 minutes after application bringing thus economic benefits.
BLOODCARE is biocompatible, biodegradable, non-acidifying haemostatic preparation of natural origin made from high quality alpha cellulose cotton. It causes no irritating reactions on the application area, is declared a hypoallergenic preparation well tolerated by the organism with no adverse effects as such that could have been reported.
BLOODCARE has bactericidal and bacteriostatic features due to the presence of carboxyl groups and low pH features, and presents also a significant effect on healing process in wounds.
Where is BLOODCARE used?
BLOODCARE products are used …
- in general surgery and digestive surgery, plastic surgery, orthopedy, gynaecology, urology, stomatology and all other branches of surgery, traumatology, and veterinary praxis
- at classical surgical procedures, at laparoscopy and endoscopy interventions as well as robotic surgery
- in dental praxis, the preparation shall be also used to arrest prolonged post-extraction capillary bleeding
- as a first aid treatment at sports, gardening, agriculture or common housework
How does BLOODCARE work?
BLOODCARE products’ effect consists in initiating and accelerating the haemocoagulation cascade.
BLOODCARE it has a significant role in starting haemocoagulation process. While applied, Factor VII is activated as well as the trombocyte activation is initiated by tissue factor. Due to anionactive characteristics of oxidised cellulose, BLOODCARE is able to form complex polymers with compounds such as fibrinogen or haemoglobin, therefore fibrinogen polymerisation is speeded up.
Calcium ions (powder and spray form) are used during protein complex fixation on cell membranes, in particular thrombocytes and endotel cells. Higher Ca2+ ion concentration stabilises activated Factor V and speeds up Factor XIII activity resulting in fibrinogen network stabilisation which is therefore able to create sufficiently organised structure for fibroblast growth and cicatrix formation. During coagulation process Ca2+ ions partially participate in thrombocyte adhesion to collagens of exposed wound, and also show partial analgesic effect. That results from ion blockage effect on autonomous nerve-endings.
How is BLOODCARE produced?
BLOODCARE products are produced by selective oxidation of high-quality cotton material (99% of cellulose content at minimum). The principle of the process selectivity means that predominantly alcoholic group on 6th carbon of basic building unit is oxidised and carboxyl is formed (-COOH). The content of -COOH is maintained at 16 – 24 volume percentage according to USP.
From the chemical point of view it is polyanhydroglucuronic acid (used for BLOODCARE matrix, BLOODCARE net and BLOODCARE wad), whose acidity is decreased by neutralisation to calcium salt (used for BLOODCARE powder and BLOODCARE spray). As free carboxyl group is a carrier of oxidised cellulose bactericidal effect, only a part of those groups is calcium bound, residual ones are free.
Does BLOODCARE have any negative impacts?
BLOODCARE shows no negative effect.
Having stopped the bleeding, BLOODCARE is “eliminated” via macrophages acting in healing – histiocytes and neutrophilic granulocytes. Biotransformation is in progress after phagocyting by tissue macrophages through depolymerisation. Cellulose chains are hydrolytically split by glycosidase into individual monomers – glucose, glucuronic acid and cellobiose which are excreted. Degraded BLOODCARE products are not detected in plasma nor urine. The preparations are fully absorbed within 12- 72 hours with no toxicology effect.